AZ7 | PI4KA inhibitor | Probechem Biochemicals

Chemical Structure : AZ7

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AZ7 (PI4KA inhibitor 7)

货号: PC-73079Not For Human Use, Lab Use Only.

AZ7 (PI4KA inhibitor 7) is a potent, selective PI4KA inhibitor with pIC50 of 8.2, >100-fold selectivity over PI4Kβ, PI3Kα and PIP5Kγ.

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生物&药学活性

AZ7 (PI4KA inhibitor 7) is a potent, selective PI4KA inhibitor with pIC50 of 8.2, >100-fold selectivity over PI4Kβ, PI3Kα and PIP5Kγ.
AZ7 inhibited the accumulation of IP1 (pIC50 6.3) caused a qualitative reduction in cellular PIP, PIP2 and PIP3 levels.
PI4KA inhibitor 7 inhibited cell growth with pGI50 values of >5.0 in 91 of the cell lines in a panel of 183 cancer cell lines.

物理化学性质&存储条件

分子量	297.376
分子式	C16H15N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-aminobenzo[d]thiazol-6-yl)-1-(cyclopropylmethyl)pyridin-2(1H)-one

参考文献

1. Michael J Waring, et al. Chem Commun (Camb). 2014 May 25;50(40):5388-90.

AZ7 (PI4KA inhibitor 7)

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物理化学性质&存储条件

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AZ7 (PI4KA inhibitor 7)

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物理化学性质&存储条件

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