AZ67 | PFKFB3 inhibitor | Probechem Biochemicals

Chemical Structure : AZ67

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AZ67 (PFKFB3 inhibitor AZ67, AZ-PFKFB3-67)

货号: PC-73057Not For Human Use, Lab Use Only.

AZ67 is a selective small molecule PFKFB3 inhibitor with IC50 of 18 nM, reduces cellular levels of F2,6BP with IC50 of 0.51 uM.

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100 mg		Get quote

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生物&药学活性

AZ67 is a potent, highly selective small molecule PFKFB3 inhibitor with IC50 of 18 nM, reduces cellular levels of F2,6BP with IC50 of 0.51 uM.
AZ67 prevents the NADPH oxidation, redox stress and apoptotic cell death caused by the activation of glycolysis triggered upon excitotoxic and oxygen-glucose deprivation/reoxygenation models in mouse primary neurons.
In vivo administration of AZ67 to mice significantly alleviated the motor discoordination and brain infarct injury in the middle carotid artery occlusion ischemia/reperfusion model.
AZ67 prevented the neuronal death triggered by the Alzheimer's disease-related peptide Aß25-35.
AZ67 did not decrease lactate production in endothelial cells (ECs), nor ATP levels, but exhibited good inhibitory efficacy in the tube-formation assay.
AZ67 demonstrated significant inhibition of angiogenesis in vivo.

物理化学性质&存储条件

分子量	455.518
分子式	C26H25N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-((3-cyano-1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-indol-5-yl)oxy)phenyl)pyrrolidine-2-carboxamide

参考文献

1. Boyd S, et al. J Med Chem. 2015 Apr 23;58(8):3611-25.

2. Burmistrova O, et al. Sci Rep. 2019 Aug 12;9(1):11670.

3. Emini Veseli B, et al. FEBS Lett. 2020 Sep;594(18):3067-3075.

4. Lopez-Fabuel I, et al. Nat Commun. 2022 Jan 27;13(1):536.

AZ67 (PFKFB3 inhibitor AZ67, AZ-PFKFB3-67)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZ67 (PFKFB3 inhibitor AZ67, AZ-PFKFB3-67)

生物&药学活性

物理化学性质&存储条件

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