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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-ERK-AZ6197
AZ6197

Chemical Structure : AZ6197

CAS No.: 2023003-94-1

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AZ6197 (AZ 6197;AZ-6197)

货号: PC-35338Not For Human Use, Lab Use Only.

AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively.
    AZ6197 demonstrates in vivo antitumor efficacy.

    物理化学性质&存储条件

    分子量 442.527
    分子式 C24H26N8O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-3-Methyl-7-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-2-((6-methylpyridin-2-yl)methyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

    参考文献

    1. Ward RA, et al. J Med Chem. 2017 Apr 27;60(8):3438-3450.

    2. Decaudin D, et al. Oncotarget. 2018 Apr 24;9(31):21674-21686.

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