AZ505 |CAS:1035227-43-0 Probechem Biochemicals

Chemical Structure : AZ505

CAS No.: 1035227-43-0

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AZ505 (AZ-505;AZ 505)

货号: PC-44245Not For Human Use, Lab Use Only.

AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2.
AZ505 suppresses BMP2-induced SMAD1/5 phosphorylation, delays cyst growth in both early- and later-stage Pkd1 conditional knockout mouse models.
AZ505 also significantly reduced tumor growth in vivo in triple-negative breast cancer (TNBC) models.

物理化学性质&存储条件

分子量	577.5424
分子式	C29H38Cl2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]-

参考文献

1. Ferguson AD, et al. Structure. 2011 Sep 7;19(9):1262-73.

2. Gao S, et al. J Biol Chem. 2017 Jul 28;292(30):12702-12712.

3. Li LX, et al. J Clin Invest. 2017 Jun 30;127(7):2751-2764.

4. Li LX, et al. Cell Death Dis. 2018 Feb 27;9(3):326.

AZ505 (AZ-505;AZ 505)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZ505 (AZ-505;AZ 505)

生物&药学活性

物理化学性质&存储条件

参考文献

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