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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Plasminogen Activator Inhibitor-1 (PAI-1)-AZ3976
AZ3976

Chemical Structure : AZ3976

CAS No.: 1418747-15-5

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AZ3976 (AZ-3976)

货号: PC-38547Not For Human Use, Lab Use Only.

AZ3976 is a small molecule inhibitor of plasminogen activator inhibitor type 1 (PAI-1) with IC50 of 26 uM in enzymatic chromogenic assay.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZ3976 is a small molecule inhibitor of plasminogen activator inhibitor type 1 (PAI-1) with IC50 of 26 uM in enzymatic chromogenic assay.
AZ3976 binds to latent PAI-1 with Kd of 0.29 uM, does not bind to active PAI-1.
AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1.

物理化学性质&存储条件

分子量 317.349
分子式 C15H19N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-butyl 3-((4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)azetidine-1-carboxylate

参考文献

1. Fjellström O, et al. J Biol Chem. 2013 Jan 11;288(2):873-85.

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