AZ39 | SMYD2 inhibitor | Probechem Biochemicals

Chemical Structure : AZ39

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AZ39 (SMYD2 inhibitor AZ39, AZ-39)

货号: PC-22291Not For Human Use, Lab Use Only.

AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.

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生物&药学活性

AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.
AZ39 is selective for SMYD2 but do possess limited activity against DOT1L, in a focused panel of KMTs including EZH2, NSD1, G9a SMYD2, and DOT1L.

物理化学性质&存储条件

分子量	560.75
分子式	C35H40N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-(4-(2-(1H-Indol-3-yl)ethyl)piperazin-1-yl)-5-cyano-N-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide

参考文献

1. Scott D. Cowen, et al. J. Med. Chem. 2016, 59, 24, 11079–11097.

AZ39 (SMYD2 inhibitor AZ39, AZ-39)

生物&药学活性

物理化学性质&存储条件

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AZ39 (SMYD2 inhibitor AZ39, AZ-39)

生物&药学活性

物理化学性质&存储条件

参考文献

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