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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Monopolar Spindle 1 (Mps1/TTK)-AZ3146
AZ3146

Chemical Structure : AZ3146

CAS No.: 1124329-14-1

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AZ3146 (AZ-3146)

货号: PC-22995Not For Human Use, Lab Use Only.

AZ3146 is a potent selective Mps1 inhibitor with IC50 of 35 nM against human Mps1Cat.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AZ3146 is a potent selective Mps1 inhibitor with IC50 of 35 nM against human Mps1Cat.
AZ3146 only inhibits FAK, JNK1, JNK2, and KIT.
AZ3146 compromises spindle assembly checkpoint (SAC) function and inhibits Mad2 localization.
AZ3146 inhibits kinetochore recruitment of O-Mad2.

物理化学性质&存储条件

分子量 452.56
分子式 C24H32N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one

参考文献

1. Hewitt L, et al. J Cell Biol. 2010 Jul 12;190(1):25-34.

2. Gurden MD, et al. Cancer Res. 2015 Aug 15;75(16):3340-54.

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