AZ194 | CRMP2-Ubc9 inhibitor | Probechem Biochemicals

Chemical Structure : AZ194

CAS No.: 2241651-99-8

加入收藏

AZ194 (CRMP2-Ubc9 inhibitor 194)

货号: PC-72811Not For Human Use, Lab Use Only.

AZ194 (CRMP2-Ubc9 inhibitor 194) is a potent and selective inhibitor of NaV1.7 currents in DRG neurons via inhibition of the CRMP2-Ubc9 interaction.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AZ194 (CRMP2-Ubc9 inhibitor 194) is a potent and selective inhibitor of NaV1.7 currents in DRG neurons via inhibition of the CRMP2-Ubc9 interaction.
Compound 194 exhibited selective in vitro and ex vivo NaV1.7 engagement.
Orally administered 194 was not only antinociceptive in preclinical models of acute and chronic pain but also demonstrated synergy alongside other analgesics-without eliciting addiction, rewarding properties, or neurotoxicity.
Compound 19 is a first-in-class protein-protein inhibitor that capitalizes on CRMP2-NaV1.7 regulation to deliver safe analgesia in rodents.
Compound 194 is a robust inhibitor of chemotherapy induced peripheral neuropathy (CIPN) that reduces established neuropathic pain and prevents the emergence of neuropathic pain during treatment with multiple anti-neoplastic agents in both mice and rats.

物理化学性质&存储条件

分子量	567.637
分子式	C34H31F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	50 mM in DMSO (28.5 mg/mL)
Chemical Name/SMILES	(4-(1-(3-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-((3-fluorobenzyl)oxy)-3-methoxyphenyl)methanone

参考文献

1. Kathryn Braden, et al. Neurobiol Pain. 2021 Dec 27;11:100082.

2. Song Cai, et al. Sci Transl Med. 2021 Nov 10;13(619):eabh1314.

AZ194 (CRMP2-Ubc9 inhibitor 194)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AZ194 (CRMP2-Ubc9 inhibitor 194)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.