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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-AZ191
AZ191

Chemical Structure : AZ191

CAS No.: 1594092-37-1

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AZ191 (AZ-191)

货号: PC-42939Not For Human Use, Lab Use Only.

AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM).
AZ191 abolishes DYRK1B drives Thr(286) phosphorylation and proteasome-dependent turnover of CCND1 (cyclin D1) in HEK-293 and PANC-1 cells, but not by GSK3β inhibitors or GSK3β RNAi.

物理化学性质&存储条件

分子量 429.5175
分子式 C24H27N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-

参考文献

1. Ashford AL, et al. Biochem J. 2014 Jan 1;457(1):43-56.

2. Li Z, et al. Cancer Lett. 2016 Jan 28;370(2):332-44.

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