AZ1729 |CAS:2016864-46-1 Probechem Biochemicals

Chemical Structure : AZ1729

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AZ1729 (AZ-1729)

货号: PC-63157Not For Human Use, Lab Use Only.

AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways.

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生物&药学活性

AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways.
AZ1729 produces stimulation of [35S]GTPγS binding with pEC50 7.23.
AZ1729 inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils.

物理化学性质&存储条件

分子量	369.418
分子式	C18H16FN5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-(2-carbamimidamido-4-methyl-1,3-thiazol-5-yl)phenyl]-4-fluorobenzamide

参考文献

1. Bolognini D, et al. J Biol Chem. 2016 Sep 2;291(36):18915-31.

AZ1729 (AZ-1729)

生物&药学活性

物理化学性质&存储条件

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AZ1729 (AZ-1729)

生物&药学活性

物理化学性质&存储条件

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