AZ1495 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : AZ1495

CAS No.: 2196204-23-4

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AZ1495 (IRAK4 inhibitor 28)

货号: PC-60013Not For Human Use, Lab Use Only.

AZ1495 is a potent, selective IRAK4 inhibitor with IC50 of 51 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZ1495 is a potent, selective IRAK4 inhibitor with IC50 of 51 nM.
AZ1495 demonstrates inhibition of NF-κB activation and growth of the ABC subtype of DLBCL cell lines in vitro in combination with ibrutinib.
AZ1495 shows tumor regression against mutant MYD88L265P DLBCL.

物理化学性质&存储条件

分子量	385.512
分子式	C21H31N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1r,4r)-4-morpholinocyclohexyl)-5-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Scott JS, et al. J Med Chem. 2017 Dec 11. doi: 10.1021/acs.jmedchem.7b01290.

AZ1495 (IRAK4 inhibitor 28)

生物&药学活性

物理化学性质&存储条件

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AZ1495 (IRAK4 inhibitor 28)

生物&药学活性

物理化学性质&存储条件

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