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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-AZ14245445
AZ14245445

Chemical Structure : AZ14245445

CAS No.:

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AZ14245445

货号: PC-23954Not For Human Use, Lab Use Only.

AZ14245445 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.9 in cellular SVD, (EGFR D770_N771insSVD) assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AZ14245445 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.9 in cellular SVD, (EGFR D770_N771insSVD) assays.

物理化学性质&存储条件

分子量 448.41
分子式 C23H15F3N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-(4-(2,6-difluorophenyl)-5-fluoropyridin-2-yl)-1-(pyrimidin-4-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)prop-2-en-1-one

参考文献

1. McCoull W, et al. J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02811.

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