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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-AZ13824374
AZ13824374

Chemical Structure : AZ13824374

CAS No.: 3040082-19-4

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AZ13824374 (AZ 13824374)

货号: PC-72779Not For Human Use, Lab Use Only.

AZ13824374 (AZ 13824374) is a potent and selective ATAD2 bromodomain inhibitor with IC50 of <7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZ13824374 (AZ 13824374) is a potent and selective ATAD2 bromodomain inhibitor with IC50 of <7 nM.
    AZ13824374 shows cellular target engagement and antiproliferative activity in a range of breast cancer models.

    物理化学性质&存储条件

    分子量 562.694
    分子式 C30H39FN8O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R,5S)-11-(8-((1-(2-Fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one

    参考文献

    1. Winter-Holt JJ, et al. J Med Chem. 2022 Feb 24;65(4):3306-3331.

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