AZ13595491 (AZ491)

Chemical Structure : AZ13595491

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货号: PC-20423Not For Human Use, Lab Use Only.

AZ13595491 (AZ491) is a potent, selective G-protein-coupled receptor GPR120 (FFAR4) agonist with IC50 of 0.74/1.0 uM for huamn/mouse GPR120, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZ13595491 (AZ491) is a potent, selective G-protein-coupled receptor GPR120 (FFAR4) agonist with IC50 of 0.74/1.0 uM for huamn/mouse GPR120, respectively.
AZ13595491 displays high selectivity over GPR40 (IC50>100 uM).
AZ13595491 (100 mg/kg) exhibited significant reduction in blood glucose excursion in response to a glucose challenge in oral glucose tolerance test (OGTT) in C57BL/6J mice.

物理化学性质&存储条件

分子量	402.43
分子式	C23H19FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2S)-2-(3-fluoro-4-(3-methyl-1-(5-methylpyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl)cyclopropanecarboxylic acid

参考文献

1. William McCoull, et al. J Med Chem. 2017 Apr 13;60(7):3187-3197.