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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-AZ 13381758
AZ 13381758

Chemical Structure : AZ 13381758

CAS No.:

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AZ 13381758 (AZ13381758;CXCR2 SM;AZ-13381758)

货号: PC-60616Not For Human Use, Lab Use Only.

A potent, small molecule CXCR2 inhibitor with IC50 of 26 nM and 30 nM for mCXCR2 and hCXCR2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AZ 13381758 is a potent, small molecule CXCR2 inhibitor with IC50 of 26 nM and 30 nM for mCXCR2 and hCXCR2, respectively.
AZ 13381758 inhibits the growth and metastatic potential pancreatic ductal adenocarcinoma, enhances sensitivity to anti-PD1 immunotherapy in vivo; chemical analog of AZD 5069.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Steele CW, et al. Cancer Cell. 2016 Jun 13;29(6):832-845.

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