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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-AZ13102909
AZ13102909

Chemical Structure : AZ13102909

CAS No.: 2322365-47-7

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AZ13102909 (AZ909)

货号: PC-38528Not For Human Use, Lab Use Only.

AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.
    AZ909 combines with AZD6244 to enhance apoptosis in AZD6244-resistant lines in 3D culture.

    物理化学性质&存储条件

    分子量 569.548
    分子式 C28H37BrN6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-((6-bromo-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)amino)propyl)cyclopentanecarboxamide

    参考文献

    1. Xu J, et al. Sci Rep. 2018 Oct 22;8(1):15587.

    2. Vu HL, Molecular cancer research: MCR. 2014;12:1509–1519.

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