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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-AZ12441970
AZ12441970

Chemical Structure : AZ12441970

CAS No.: 929551-91-7

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AZ12441970 (AZ 12441970;AZ-12441970)

货号: PC-63386Not For Human Use, Lab Use Only.

AZ12441970 is a selective TLR7 agonist with pEC50 of 6.8 and 6.6 for human and rat TLR7, shows inactivity against TLR8.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZ12441970 is a selective TLR7 agonist with pEC50 of 6.8 and 6.6 for human and rat TLR7, shows inactivity against TLR8.
    AZ12441970 sufficiently activates the IFN pathway.
    AZ12441970 shows efficacy in a mouse allergic airway model with minimal induction of systemic IFN-α.

    物理化学性质&存储条件

    分子量 527.67
    分子式 C27H41N7O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl 2-(3-(((3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl)(3-(dimethylamino)propyl)amino)methyl)phenyl)acetate

    参考文献

    1. Biffen M, et al. Br J Pharmacol. 2012 May;166(2):573-86.

    2. Edwards S, et al. J Immunol. 2013 Mar 15;190(6):2585-92.

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