AZ12436092 | CCR3 antagonist | Probechem Biochemicals

Chemical Structure : AZ12436092

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AZ12436092 (AZ 12436092)

货号: PC-20727Not For Human Use, Lab Use Only.

AZ12436092 (AZ 12436092) is a potent, selective CCR3 antagonist with binding pKi value of 9.2.

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生物&药学活性

AZ12436092 (AZ 12436092) is a potent, selective CCR3 antagonist with binding pKi value of 9.2.
AZ12436092 shows no additional activities against a panel of >100 GPCR receptors, and very weak activity at the hERG channel (pIC50=4.5) and H binding (pKi=6.8).
AZ12436092 inhibits CCL-24 (eotaxin-2) induced shape-change of eosinophils in human blood (pA2=7.9).
AZ12436092 displays excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.

物理化学性质&存储条件

分子量	503.06
分子式	C28H36ClFN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)[C@@](C)(N1CCC(CN2CCC(OC3=CC=C(Cl)C=C3C)CC2)CC1)CC4=CC=C(F)C=C4

参考文献

1. Ash Bahl, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9.

AZ12436092 (AZ 12436092)

生物&药学活性

物理化学性质&存储条件

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AZ12436092 (AZ 12436092)

生物&药学活性

物理化学性质&存储条件

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