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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-AZ12204657
AZ12204657

Chemical Structure : AZ12204657

CAS No.: 847148-49-6

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AZ12204657 (AZ-12204657, AZ 12204657)

货号: PC-35910Not For Human Use, Lab Use Only.

AZ12204657 (AZ-12204657) small-molecule GPR44 antagonist, displaces the binding of [3H]PGD2 from membranes of HEK293 cells transfected with human recombinant GPR44 with IC50 of 2.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZ12204657 (AZ-12204657) is a small-molecule GPR44 antagonist, displaces the binding of [3H]PGD2 from membranes of HEK293 cells transfected with human recombinant GPR44 with IC50 of 2.5 nM.
    [11C]AZ12204657 is a potential PET radioligand for the beta cell-restricted protein GPR44.

    物理化学性质&存储条件

    分子量 405.242
    分子式 C16H14Cl2O6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(4-chloro-2-(2-chloro-4-(methylsulfonyl)phenoxy)phenoxy)propanoic acid

    参考文献

    1. Eriksson O, et al. Diabetes. 2018 Feb;67(2):182-192.

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