AZ11645373 | P2X7 antagonist | Probechem Biochemicals

Chemical Structure : AZ11645373

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AZ11645373 (AZ 11645373)

货号: PC-22910Not For Human Use, Lab Use Only.

AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM.

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生物&药学活性

AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM.
AZ11645373 has no agonist or antagonist actions on membrane currents due to P2X receptor activation at human P2X(1), rat P2X(2), human P2X(3), rat P2X(2/3), human P2X(4), or human P2X(5) receptors expressed in HEK cells.
AZ11645373 inhibits ATP- or BzATP-evoked YO-PRO1 fluorescence in HEK cells stably expressing hP2X7R, but not rP2X7R-expressing cells.
AZ11645373 is highly effective at inhibiting ATP- and BzATP-mediated responses in all our assays on hP2X7Rs, with IC50/KB values ranging from 5 to 90 nM depending on the specific assay.

物理化学性质&存储条件

分子量	463.51
分子式	C24H21N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-((3'-Nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione

参考文献

1. Laurent C, et al. Br J Pharmacol. 2006 Dec;149(7):880-7.

AZ11645373 (AZ 11645373)

生物&药学活性

物理化学性质&存储条件

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AZ11645373 (AZ 11645373)

生物&药学活性

物理化学性质&存储条件

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