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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-AZ10606120 dihydrochloride
AZ10606120 dihydrochloride

Chemical Structure : AZ10606120 dihydrochloride

CAS No.: 607378-18-7

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AZ10606120 dihydrochloride (AZ 10606120, AZ-10606120)

货号: PC-63426Not For Human Use, Lab Use Only.

AZ10606120 dihydrochloride is a potent, specific P2X7 receptor antagonist with Kd of 1.4 and 19 nM at human and rat P2X7 receptors respectively.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZ10606120 dihydrochloride is a potent, specific P2X7 receptor antagonist with Kd of 1.4 and 19 nM at human and rat P2X7 receptors respectively.
AZ10606120 strongly inhibits tumor growth in B16-inoculated C57Bl/6 mice.

物理化学性质&存储条件

分子量 495.489
分子式 C25H36Cl2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride

参考文献

1. Yan Z, et al. J Neurosci. 2010 Oct 20;30(42):14213-24.

2. Mohammed A, et al. Oncotarget. 2017 Oct 26;8(58):97822-97834.

3. Adinolfi E, et al. Cancer Res. 2012 Jun 15;72(12):2957-69.

4. Michel AD, et al. Br J Pharmacol. 2008 Feb;153(4):737-50.

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