AZ10397767 (AZ767) | CXCR2 antagonist | Probechem Biochemicals

Chemical Structure : AZ10397767

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AZ10397767 (AZ-10397767, AZ767, AZ-767)

货号: PC-60617Not For Human Use, Lab Use Only.

AZ10397767 (AZ767) is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0.

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生物&药学活性

AZ10397767 (AZ767) is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0.
AZ10397767 weakly inhibits CXCL8 binding to CXCR1 with pIC50<7, and no affinity for CCR2 and CCR5.
AZ10397767 significantly attenuates IL-8-induced c-FLIP mRNA up-regulation whereas inhibition of AR- and/or NF-kappaB-mediated transcription attenuated IL-8-induced c-FLIP expression in LNCaP and PC3 cells, respectively.
AZ10397767 attenuates oxaliplatin-induced NF-kappaB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells.

物理化学性质&存储条件

分子量	400.871
分子式	C15H14ClFN4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R)-5-[[(3-chloro-2-fluorophenyl)methyl]thio]-7-[[2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one

参考文献

1. Wilson C, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):746-59.

2. Seaton A, et al. Carcinogenesis. 2008 Jun;29(6):1148-56.

3. Wilson C, et al. Mol Cancer Ther. 2008 Sep;7(9):2649-61.

4. Walters I, et la. Bioorg Med Chem Lett. 2008 Jan 15;18(2):798-803.

AZ10397767 (AZ-10397767, AZ767, AZ-767)

生物&药学活性

物理化学性质&存储条件

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AZ10397767 (AZ-10397767, AZ767, AZ-767)

生物&药学活性

物理化学性质&存储条件

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