AZ-628 | pan-RAF inhibitor | Probechem Biochemicals

Chemical Structure : AZ-628

CAS No.: 878739-06-1

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AZ-628 (AZD-628, AZ628, AZD628)

货号: PC-73450Not For Human Use, Lab Use Only.

AZ628 (AZD-628) is a potent, selective, pan-RAF kinase inhibitor with IC50 of 105, 29 and 34 nM against for wild-type CRAF, BRAF V600E, and c-Raf-1, respectively.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

AZ-628 (AZD-628) is a potent, selective, pan-RAF kinase inhibitor with IC50 of 105, 29 and 34 nM against for wild-type CRAF, BRAF V600E, and c-Raf-1, respectively.
AZ628 prevents activation of number of tyrosine protein kinases including VEGFR2, DDR2, Lyn, Flt1, FMS and others.
AZ628 suppresses anchorage-dependent and -independent growth, gives rise to cell cycle arrest, and induces apoptosis in colon and melanoma cell lines harboring B-RafV600E mutation.
AZ628 effectively suppressed p-ERK1/2 levels in the M14 parental cell line.

物理化学性质&存储条件

分子量	451.530
分子式	C27H25N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide

参考文献

1. Daniel J Anderson, et al. PLoS One. 2011;6(8):e22607.

2. Vladimir Khazak, et al. Expert Opin Ther Targets. 2007 Dec;11(12):1587-609.

3. Clara Montagut, et al. Cancer Res. 2008 Jun 15;68(12):4853-61.

AZ-628 (AZD-628, AZ628, AZD628)

生物&药学活性

物理化学性质&存储条件

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AZ-628 (AZD-628, AZ628, AZD628)

生物&药学活性

物理化学性质&存储条件

参考文献

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