AZ-1 | ABCA1/apoE inducer |Probechem Biochemicals

Chemical Structure : AZ-1

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AZ-1 (ABCA1/apoE inducer AZ-1)

货号: PC-63495Not For Human Use, Lab Use Only.

AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity.

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生物&药学活性

AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity.
AZ-1 upregulates ABCA1 across multiple CNS cell types, including human astrocytes, pericytes, and microglia, through an indirect LXR mechanism and that also independently inhibit P2X7 receptor activity.

物理化学性质&存储条件

分子量	430.977
分子式	C23H31ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(6-chloro-2-(3-((2-hydroxyethyl)amino)pyrrolidin-1-yl)quinolin-5-yl)-2-cyclohexylacetamide

参考文献

1. Fan J, et al. J Lipid Res. 2018 May;59(5):830-842.

AZ-1 (ABCA1/apoE inducer AZ-1)

生物&药学活性

物理化学性质&存储条件

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AZ-1 (ABCA1/apoE inducer AZ-1)

生物&药学活性

物理化学性质&存储条件

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