AY9944 | DHCR7 inhibitor | Probechem Biochemicals

Chemical Structure : AY9944

CAS No.: 366-93-8

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AY9944 (AY-9944)

货号: PC-62176Not For Human Use, Lab Use Only.

AY9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

AY9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling.
AY9944 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome in animal model.

物理化学性质&存储条件

分子量	464.3
分子式	C22H28Cl2N2 • 2HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride

参考文献

1. Horlick L. J Lipid Res. 1966 Jan;7(1):116-21.

2. Lauth M, et al. Mol Pharmacol. 2010 Sep;78(3):486-96.

3. Xu L, et al. J Lipid Res. 2011 Oct;52(10):1810-20.

AY9944 (AY-9944)

生物&药学活性

物理化学性质&存储条件

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AY9944 (AY-9944)

生物&药学活性

物理化学性质&存储条件

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