AXKO-0046 | LDHB inhibitor | Probechem Biochemicals

Chemical Structure : AXKO-0046

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AXKO-0046 (AXKO0046)

货号: PC-72514Not For Human Use, Lab Use Only.

AXKO-0046 (AXKO0046) is the first highly selective, small molecule inhibitor of human lactate dehydrogenase B (LDHB), exhibits uncompetitive LDHB inhibition with EC50 of 42 nM.

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2 mg	￥3580	In stock
5 mg	￥5580	In stock
10 mg	￥8980	In stock
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100 mg		Get quote

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生物&药学活性

AXKO-0046 (AXKO0046) is the first highly selective, small molecule inhibitor of human lactate dehydrogenase B (LDHB), exhibits uncompetitive LDHB inhibition with EC50 of 42 nM.
AXKO-0046 selectively inhibited LDHB activity in an uncompetitive manner with respect to NADH and pyruvate, no inhibitory activity against LDHA at 300 uM.
AXKO-0046 did not bind in the catalytic site of the enzyme but significantly bound to LDHB in the novel allosteric site of the tetramer.
AXKO-0046 is a promising chemical probe to elucidate the role of LDHB-associated pathways in cancer metabolism.

物理化学性质&存储条件

分子量	375.56
分子式	C25H33N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-({3-[2-(benzylamino) ethyl]-1H-indol-2-yl} methyl) cycloheptanamine

参考文献

1. Sachio Shibata, et al. Sci Rep. 2021 Nov 1;11(1):21353.

AXKO-0046 (AXKO0046)

生物&药学活性

物理化学性质&存储条件

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AXKO-0046 (AXKO0046)

生物&药学活性

物理化学性质&存储条件

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