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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-AX-35
AX-35

Chemical Structure : AX-35

CAS No.: 1049986-24-4

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AX-35 (GW861072X)

货号: PC-28676Not For Human Use, Lab Use Only.

AX-35 (GW861072X) is a potent M. tuberculosis inhibitor targeting the QcrB subunit of the cytochrome bc1 oxidase, has MIC of 0.05 ug/ml against M. tuberculosis H37Rv and 0.1 ug/mL for M. tuberculosis H37Rv-infected THP-1 macrophages.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AX-35 (GW861072X) is a potent M. tuberculosis inhibitor targeting the QcrB subunit of the cytochrome bc1 oxidase, has MIC of 0.05 ug/ml against M. tuberculosis H37Rv and 0.1 ug/mL for M. tuberculosis H37Rv-infected THP-1 macrophages.

物理化学性质&存储条件

分子量 356.44
分子式 C19H20N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one

参考文献

1. Foo CS, et al. mBio. 2018 Oct 9;9(5):e01276-18.

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