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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-ERK-AX-15836
AX-15836

Chemical Structure : AX-15836

CAS No.: 2035509-96-5

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AX-15836 (AX15836)

货号: PC-70300Not For Human Use, Lab Use Only.

AX-15836 (AX15836) is a potent, highly selective ERK5 inhibitor with IC50 of 8 nM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AX-15836 (AX15836) is a potent, highly selective ERK5 inhibitor with IC50 of 8 nM.
AX-15836 shows little affinity for BRD4 (Kd=3.6 uM).
AX-15836 clearly inhibits the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells.

物理化学性质&存储条件

分子量 648.783
分子式 C32H40N8O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-11-(methylsulfonyl)-

参考文献

1. Lin EC, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870.

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