AX-024 | TCR inhibitor | Probechem Biochemicals

Chemical Structure : AX-024

CAS No.: 1370544-73-2

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AX-024 (AX 024, AX024)

货号: PC-60400Not For Human Use, Lab Use Only.

AX-024 (AX024) is a first-in-class, specific inhibitor of T cell receptor (TCR), specifically inhibits TCR-Nck (SH3.1) interaction and TCR-dependent T cell activation (IC50=1 nM).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
50 mg	￥3780	In stock
100 mg	￥5580	In stock
250 mg		Get quote

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生物&药学活性

AX-024 (AX024) is a first-in-class, specific inhibitor of T cell receptor (TCR), specifically inhibits TCR-Nck (SH3.1) interaction and TCR-dependent T cell activation (IC50=1 nM).

AX-024 does not inhibit BCR-triggered B cell proliferation mediated by the SH2 domain of Nck.

AX-024 inhibits the recruitment of endogenous Nck to CD3e, and therefore to the TCR.

Oral administration of AX-024 prevents the development of neurological symptoms in a model of multiple sclerosis (MS).

AX-024 exerts a long-lasting therapeutic effect in the EAE model of MS.

物理化学性质&存储条件

分子量	339.41
分子式	C21H22FNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine

参考文献

1. Borroto A, et al. Sci Transl Med. 2016 Dec 21;8(370):370ra184.

AX-024 (AX 024, AX024)

生物&药学活性

物理化学性质&存储条件

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AX-024 (AX 024, AX024)

生物&药学活性

物理化学性质&存储条件

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