AVN-944 (VX-944) | IMPDH inhibitor | Probechem Biochemicals

Chemical Structure : AVN-944

CAS No.: 297730-17-7

加入收藏

AVN-944 (VX-944, AVN944, VX944)

货号: PC-49656Not For Human Use, Lab Use Only.

AVN-944 (VX-944) is a potent, selective, noncompetitive inhibitor of both human inosine 5-monophosphate dehydrogenase (IMPDH) isoforms (Ki=6-10 nM).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AVN-944 (VX-944) is a potent, selective, noncompetitive inhibitor of both human inosine 5-monophosphate dehydrogenase (IMPDH) isoforms (Ki=6-10 nM).
AVN-944 (VX-944) significantly inhibited the growth of MM cell lines RPMI8226, MM.1S, and U266 cells in a dose-dependent fashion with IC50 of 450, 450, and 600 nM (48h),respectively.
AVN-944 (VX-944) also inhibited growth of drugresistant cell lines, including doxorubicin (Dox)-resistant RPMI8226-Dox40, melphalan (Mel) resistant
RPMI8226-LR5, and Dex (dexamethasone) resistant MM.1R cells, with IC50 values similar to the parental drug-sensitive cell lines.
AVN-944 (VX-944) induced caspase-independent apoptosis in MM cells, induced modest cleavage of caspase 3, 8 and 9, enhances expression of Bax and Bak proteins.
AVN-944 (VX-944) augmented the cytotoxicity of doxorubicin and melphalan even in the presence of BMSCs.
AVN-944 (VX-944) also inhibits ZIKV Replication against ZIKV Paraiba/2015 in A549 cells.

物理化学性质&存储条件

分子量	477.52
分子式	C25H27N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R)-1-(Cyanomethyl)propyl N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]carbamate

参考文献

1. Kenji Ishitsuka, et al. Oncogene. 2005 Sep 1;24(38):5888-96.

2. Park JG, et al. J Virol. 2020 Mar 17;94(7):e02149-19.

3. Morales Vasquez D, et al. Viruses. 2020 Sep 18;12(9):1041.

AVN-944 (VX-944, AVN944, VX944)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AVN-944 (VX-944, AVN944, VX944)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.