AVN-492 | 5-HT6 antagonist | Probechem Biochemicals

Chemical Structure : AVN-492

CAS No.: 1220646-23-0

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AVN-492 (AVN492)

货号: PC-73302Not For Human Use, Lab Use Only.

AVN-492 is a highly potent and selective 5-HT6 receptor antagonist with Ki of 91 pM, >1000-fold selectivity over 5-HT2BR (Ki=170 nM).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

AVN-492 is a highly potent and selective 5-HT6 receptor antagonist with Ki of 91 pM, >1000-fold selectivity over 5-HT2BR (Ki=170 nM).
AVN-492 displays great 5-HT6R selectivity against all other serotonin receptor subtypes, and is extremely specific against any other receptors such as adrenergic, GABAergic, dopaminergic, histaminergic, etc.
AVN-492 demonstrates good in vitro and in vivo ADME profile with high oral bioavailability and good brain permeability in rodents.
AVN-492 shows anxiolytic effect in elevated plus-maze model, prevents an apomorphine-induced disruption of startle pre-pulse inhibition (the PPI model) and reverses a scopolamine- and MK-801-induced memory deficit in passive avoidance model.

物理化学性质&存储条件

分子量	359.448
分子式	C17H21N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2,N6,N6,5,7-Pentamethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine-2,6-diamine

参考文献

1. Ivachtchenko AV, et al. J Alzheimers Dis. 2017;58(4):1043-1063.

AVN-492 (AVN492)

生物&药学活性

物理化学性质&存储条件

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AVN-492 (AVN492)

生物&药学活性

物理化学性质&存储条件

参考文献

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