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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-AVN-322
AVN-322

Chemical Structure : AVN-322

CAS No.: 1194574-68-9

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AVN-322 (AVN322)

货号: PC-61502Not For Human Use, Lab Use Only.

AVN-322 is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AVN-322 is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.
    AVN-322 significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.

    物理化学性质&存储条件

    分子量 393.89
    分子式 C17H20ClN5O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine hydrochloride

    参考文献

    1. Ivachtchenko AV, et al. Curr Alzheimer Res. 2017;14(3):268-294.

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