AVN-211 |CAS:1173103-84-8 Probechem Biochemicals

Chemical Structure : AVN-211

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AVN-211 (AVN211;CD-008-0173)

货号: PC-61511Not For Human Use, Lab Use Only.

AVN-211 (CD-008-0173) is a novel and highly selective 5-HT6 receptor small molecule antagonist with Ki of 2.34 nM.

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生物&药学活性

AVN-211 (CD-008-0173) is a novel and highly selective 5-HT6 receptor small molecule antagonist with Ki of 2.34 nM.
AVN-211 shows a similar or better anxiolytic efficacy than fenobam, rufinamide, lorazepam, and buspirone in an elevated plus-maze model.
AVN-211 significantly delayes or partially halts the progressive decline in memory function associated with AD.

物理化学性质&存储条件

分子量	333.424
分子式	C15H15N3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,7-Dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine

参考文献

1. Ivachtchenko AV, et al. Mol Pharm. 2016 Mar 7;13(3):945-63.

2. Morozova MA,et al. CNS Spectr. 2014 Aug;19(4):316-23.

AVN-211 (AVN211;CD-008-0173)

生物&药学活性

物理化学性质&存储条件

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AVN-211 (AVN211;CD-008-0173)

生物&药学活性

物理化学性质&存储条件

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