AVL-292 besylate (Spebrutinib) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : AVL-292 besylate

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AVL-292 besylate (Spebrutinib besylate, CC-292 besylate)

货号: PC-45402Not For Human Use, Lab Use Only.

AVL-292 besylate (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM.

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生物&药学活性

AVL-292 besylate (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM.
AVL-292 besylate (Spebrutinib, CC-292) also less potently inhibits Yes, c-Src, Brk, Lyn, and Fyn with IC50s of 723 nM, 1.729 uM, 2.43 uM, 4.4 uM, and 7.15 uM, rspectively.
AVL-292 besylate (Spebrutinib, CC-292) shows anti-inflammatory activity in the collagen-induced arthritis model of autoimmune disease.
AVL-292 besylate (Spebrutinib, CC-292) also prevents NRG- and EGF-dependent growth factor-driven resistance to lapatinib in HER2(+) breast cancer cells.

物理化学性质&存储条件

分子量	581.6152
分子式	C28H28FN5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, benzenesulfonate (1:1)

参考文献

1. Evans EK, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28.

2. Eda H, et al. Leukemia. 2014 Sep;28(9):1892-901.

3. Wang X, et al. Mol Cancer Ther. 2016 Sep;15(9):2198-208.

AVL-292 besylate (Spebrutinib besylate, CC-292 besylate)

生物&药学活性

物理化学性质&存储条件

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AVL-292 besylate (Spebrutinib besylate, CC-292 besylate)

生物&药学活性

物理化学性质&存储条件

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