AVJ16 | Igf2bp1 inhibitor | Probechem Biochemicals

Chemical Structure : AVJ16

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AVJ16 (IGF2BP1 inhibitor AVJ 16)

货号: PC-21375Not For Human Use, Lab Use Only.

AVJ16 is a specific and potent IGF2BP1 inhibitor, inhibits H1299 wound healing with IC50 of 0.7 uM, interacts with recombinant IGF2BP1 protein with KD of 1.4 uM in MST assays.

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生物&药学活性

AVJ16 is a specific and potent IGF2BP1 inhibitor, inhibits H1299 wound healing with IC50 of 0.7 uM, interacts with recombinant IGF2BP1 protein with KD of 1.4 uM in MST assays.
AVJ16 is 14 times more effective than 7773 (Cat#PC-20553).
AVJ16 interacts with IGF2BP1 KH34 di-domain.
AVJ16 (1.5 uM, 48 h) downregulates Kras and other IGF2BP1 target RNAs, Kras RNA and protein in H1299 cells.
AVJ16 inhibits tumorigenic properties of cancer cells in IGF2BP1-dependent manner, does not affect cell growth in LKR-M-GFP cells that do not express IGF2BP1.

物理化学性质&存储条件

分子量	469.54
分子式	C28H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(Benzo[d] [1,3]dioxol-5-yl)piperazin-1-yl) (4-((3-(hydroxymethyl)-1H-indol-1-yl) methyl)phenyl)methanone

参考文献

1. Singh A, et al. Eur J Med Chem. 2023 Nov 10;263:115940.

AVJ16 (IGF2BP1 inhibitor AVJ 16)

生物&药学活性

物理化学性质&存储条件

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AVJ16 (IGF2BP1 inhibitor AVJ 16)

生物&药学活性

物理化学性质&存储条件

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