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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-AVI-4206
AVI-4206

Chemical Structure : AVI-4206

CAS No.:

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AVI-4206 (AVI 4206)

货号: PC-22947Not For Human Use, Lab Use Only.

AVI-4206 is a potent, specific small molecule inhibitor of SARS-CoV-2 ADP-ribosylhydrolase macrodomain (Mac1) with IC50 of 20 nM in HTRF assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AVI-4206 is a potent, specific small molecule inhibitor of SARS-CoV-2 ADP-ribosylhydrolase macrodomain (Mac1) with IC50 of 20 nM in HTRF assays.
AVI-4206 potently inhibits Mac1 with IC50 of 64 nM used auto ADP-ribosylated PARP10 and a coupled NudT5/AMP-Glo assay.
AVI-4206 engages Mac1 in cells with high specificity. an weakly inhibit viral replication in a gamma interferon- and Mac1 catalytic activity-dependent manner.
AVI-4206 reduces viral replication, potentiates innate immune responses, and leads to a survival benefit, in animal model of severe SARS-CoV-2 infection.

物理化学性质&存储条件

分子量 381.44
分子式 C19H23N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-((2,2-dimethyl-5-oxopyrrolidin-1-yl)amino)-9H-pyrimido[4,5-b]indol-8-yl)-3-ethylurea

参考文献

1. Suryawanshi RK, et al. bioRxiv [Preprint]. 2024 Aug 9:2024.08.08.606661.

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