AVG-233 | RSV RdRp inhibitor | Probechem Biochemicals

Chemical Structure : AVG-233

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AVG-233 (AVG-233)

货号: PC-35776Not For Human Use, Lab Use Only.

AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM).
AVG-233 exhibits 34% oral bioavailability and sustained high drug levels in the circulation after a single oral dose of 20 mg/kg.

物理化学性质&存储条件

分子量	487.944
分子式	C26H22ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((6-chloropyridin-2-yl)methyl)-1-(4-methoxybenzyl)-4-methyl-2-(pyridin-2-yl)-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione

参考文献

1. Cox RM, et al. J Biol Chem. 2018 Oct 26;293(43):16761-16777.

AVG-233 (AVG-233)

生物&药学活性

物理化学性质&存储条件

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AVG-233 (AVG-233)

生物&药学活性

物理化学性质&存储条件

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