AVE-0118 |CAS:498577-53-0 Probechem Biochemicals

Chemical Structure : AVE-0118

CAS No.: 498577-53-0

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AVE-0118 (AVE0118)

货号: PC-62817Not For Human Use, Lab Use Only.

AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4380	In stock
100 mg		Get quote

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生物&药学活性

AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency.
AVE-0118 dose-dependently prolongs the atrial refractoriness independent from rate and inhibits left atrial vulnerability (LAV) in vivo.
AVE-0118 fully restored atrial contraction without proarrhythmic effects on the ventricle.

物理化学性质&存储条件

分子量	479.58
分子式	C30H29N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-[[2-(4-Methoxyphenyl)acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide

参考文献

1. de Haan S, et al. Circulation. 2006 Sep 19;114(12):1234-42.

2. Decher N, et al. Mol Pharmacol. 2006 Oct;70(4):1204-11.

3. Wettwer E, et al. Circulation. 2004 Oct 19;110(16):2299-306.

4. Wirth KJ, et al. Cardiovasc Res. 2003 Nov 1;60(2):298-306.

AVE-0118 (AVE0118)

生物&药学活性

物理化学性质&存储条件

参考文献

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AVE-0118 (AVE0118)

生物&药学活性

物理化学性质&存储条件

参考文献

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