AUTEN-67 |CAS:1783800-77-0 Probechem Biochemicals

Chemical Structure : AUTEN-67

CAS No.: 1783800-77-0

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AUTEN-67 (Autophagy Enhancer 67;AUTEN67)

货号: PC-60217Not For Human Use, Lab Use Only.

AUTEN-67 is a small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

AUTEN-67 is a small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14.
At concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
AUTEN-67 shows no activity for CDC25B , other phosphatase, PTPN1.
AUTEN-67 significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death.
AUTEN-67 also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.

物理化学性质&存储条件

分子量	474.45
分子式	C23H14N4O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1H-benzo[d]imidazol-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-nitrobenzenesulfonamide

参考文献

1. Papp D, et al. Autophagy. 2016;12(2):273-86.

2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47.

AUTEN-67 (Autophagy Enhancer 67;AUTEN67)

生物&药学活性

物理化学性质&存储条件

参考文献

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AUTEN-67 (Autophagy Enhancer 67;AUTEN67)

生物&药学活性

物理化学性质&存储条件

参考文献

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