AUT00201 | Kv3 modulator | Probechem Biochemicals

Chemical Structure : AUT00201

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AUT00201 (AUT 00201, AUT-00201)

货号: PC-21564Not For Human Use, Lab Use Only.

AUT00201 is a potent, selective Kv3 potassium channels positive allosteric modulator (PAM), increases the Kv3.1, Kv3.2 and Kv3.4 currents measured at -15mV in a concentration-dependent manner with pEC50 values of 6.15, 6.52, and 5.6, respectively.

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生物&药学活性

AUT00201 is a potent, selective Kv3 potassium channels positive allosteric modulator (PAM), increases the Kv3.1, Kv3.2 and Kv3.4 currents measured at -15mV in a concentration-dependent manner with pEC50 values of 6.15, 6.52, and 5.6, respectively.

AUT00201 also modulates human Kv3.2 and Kv3.4 channels with different potencies.

AUT00201 (5 and 20 mg/kg) attenuates motor dysfunction, motor neuron loss and muscle pathology in SOD1-G93A mice.

AUT00201 improves the phenotype of amyotrophic lateral sclerosis (ALS) mice specifically.

物理化学性质&存储条件

分子量	380.40
分子式	C20H20N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-ethyl-3-(2-((7-methyl-2H-spiro[benzofuran-3,1'-cyclopropan]-4-yl)oxy)pyrimidin-5-yl)imidazolidine-2,4-dione

参考文献

1. Patent WO2012076877 A1.

AUT00201 (AUT 00201, AUT-00201)

生物&药学活性

物理化学性质&存储条件

参考文献

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AUT00201 (AUT 00201, AUT-00201)

生物&药学活性

物理化学性质&存储条件

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