欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-ATX968
ATX968

Chemical Structure : ATX968

CAS No.: 2973395-71-8

加入收藏

ATX968 (ATX-968)

货号: PC-23517Not For Human Use, Lab Use Only.

ATX968 is a potent and selective inhibitor of DHX9 helicase activity with DHX9 unwinding IC50 of 8 nM, SPR Kd value of 1.3 nM.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ATX968 is a potent and selective inhibitor of DHX9 helicase activity with DHX9 unwinding IC50 of 8 nM, SPR Kd value of 1.3 nM.
ATX968 is not competitive with nucleotide triphosphate substrates.
ATX968 shows similar affinity and binding kinetics to mouse DHX9 as to human DHX9, extending its potential utility to studies in mouse models.
ATX968 exhibits no significant inhibition against DHX36, a DExH-box RNA helicase related to DHX9, SMARCA2, a DNA helicase, as well as a panel of 97 kinases.
ATX968 treatment revealed a concentration-dependent induction of the Alu-mediated circRNAs (EC50= 101 nM, 95 nM and 236 nM for circBRIP1, circAKR1A and circDKC1 respectively), but no effect on the non–Alu mediated circSETD3 or the corresponding linear transcripts.
TX968 treatment leads to replication stress and DNA damage in multiple MSI-H/dMMR cell lines, induces selective inhibition of proliferation in multiple MSI-H/dMMR indications.
ATX968 exhibits significant and durable tumor regression in MSI-H/dMMR xenograft model but not in a microsatellite stable (MSS)/proficient mismatch repair (pMMR) model.

物理化学性质&存储条件

分子量 421.91
分子式 C18H16ClN3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-chloro-5-(methylsulfonamido)phenyl)-4-(3-methylpyridin-2-yl)thiophene-2-carboxamide

参考文献

1. Castro J, et al. Cancer Res. 2024 Nov 26. doi: 10.1158/0008-5472.CAN-24-0397.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: