ATX020 | KIF18A inhibitor | Probechem Biochemicals

Chemical Structure : ATX020

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ATX020 (ATX-020)

货号: PC-25729Not For Human Use, Lab Use Only.

ATX020 (ATX-020) is a potent, selective and orally efficacious KIF18A (kinesin-like protein 18A) inhibitor with IC50 of 0.11 uM and 0.16 uM for human and rat KIF18A respectively.

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生物&药学活性

ATX020 (ATX-020) is a potent, selective and orally efficacious KIF18A (kinesin-like protein 18A) inhibitor with IC50 of 0.11 uM and 0.16 uM for human and rat KIF18A respectively.
ATX020 displays little to no activity against CENP-E, Eg5, KIF15, KIF18B and KIF19 (IC50>5 uM).
ATX020 displays potent antiproliferative activity against the KIF18A-sensitive OVCAR-8 and AU565 cell lines with IC50 of 0.09 and 0.21 uM respectively.
ATX020 (30 and 100 mg/kg, po q.d. dosing) displays robust tumor growth inhibition on OVCAR-3 CDX tumor model.

物理化学性质&存储条件

分子量	581.75
分子式	C26H37F2N5O4SSi
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(4,4-difluorocyclohexyl)-6-methylpyrimidin-4-yl)-2-(4,4-dimethyl-1,4-azasilinan-1-yl)-4-((2-hydroxyethyl)sulfonamido)benzamide

参考文献

1. Sparling BA, et al. ACS Med Chem Lett. 2025 Oct 27;16(11):2309-2319.

ATX020 (ATX-020)

生物&药学活性

物理化学性质&存储条件

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ATX020 (ATX-020)

生物&药学活性

物理化学性质&存储条件

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