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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Nitric Oxide Synthase (NOS)-ATV399
ATV399

Chemical Structure : ATV399

CAS No.: 393834-37-2

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ATV399 (ATV 399;ATV-399)

货号: PC-35192Not For Human Use, Lab Use Only.

ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase 9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase 9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS.
    ATV399 inhibits cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose.

    物理化学性质&存储条件

    分子量 465.524
    分子式 C24H23N3O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((2-(pyridin-3-yl)piperidin-1-yl)sulfonyl)phenyl)benzo[d][1,3]dioxole-5-carboxamide

    参考文献

    1. Zhong L, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14388.

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