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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-ATUX-1215
ATUX-1215

Chemical Structure : ATUX-1215

CAS No.: 2910930-01-5

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ATUX-1215 (ATUX1215)

货号: PC-21366Not For Human Use, Lab Use Only.

ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.
    ATUX-1215 (1 uM) induces PP2A phosphatase activity responses in fibroblasts, reduced the level of TGFβ induction of ACTA2, COL1A1, COL1A2, and FN1 gene expression in fibroblasts.
    ATUX-1215 activates PP2A responses in the BLM model and elicited potentially useful therapeutic effects.
    ATUX-1215 (5 mg/kg, daily, oral) reduces the BLM-induced BALF levels of IL12p70, GM-CSF, and IL-1α in C57BL/6J mice.
    ATUX-1215 shows the improved metabolic stability and bioavailability of ATUX-1215 to previously described PP2A activators.
    ATUX-1215 prevents BLM-induced lung physiology changes, including the preservation of normal PV loop, compliance, tissue elastance, and forced vital capacity.

    物理化学性质&存储条件

    分子量 553.54
    分子式 C27H24F5NO4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Benzenesulfonamide, N-[(2R,4S)-2-(2,8-difluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)tetrahydro-2H-pyran-4-yl]-4-(trifluoromethoxy)-

    参考文献

    1. Meshach Pillai, et al. ACS Pharmacol Transl Sci. 2023 Oct 17;6(11):1659-1672.

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