ATN-224 |CAS:649749-10-0 Probechem Biochemicals

Chemical Structure : ATN-224

CAS No.: 649749-10-0

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ATN-224 (Choline tetrathiomolybdate, WTX-101)

货号: PC-61677Not For Human Use, Lab Use Only.

ATN-224 (Choline tetrathiomolybdate, WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects.

规格	价格	库存
5 mg	￥2880	In stock
10 mg	￥4280	In stock
25 mg		Get quote
10 mg		Get quote

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生物&药学活性

ATN-224 (Choline tetrathiomolybdate, WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects.
ATN-224 shows no binding to calcium, iron, magnesium, zinc, or manganese ions at 1 mM.
ATN-224 inhibits HUVEC proliferation with IC50 1.4 uM.
ATN-224 shows a potential therapy against Wilson's disease.

物理化学性质&存储条件

分子量	432.542
分子式	C10H28MoN2O2S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate

参考文献

1. Juarez JC, et al. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.

2. Doñate F, et al. Br J Cancer. 2008 Feb 26;98(4):776-83.

3. Calderon-Aparicio A, et al. Oncotarget. 2015 Oct 6;6(30):29771-81.

ATN-224 (Choline tetrathiomolybdate, WTX-101)

生物&药学活性

物理化学性质&存储条件

参考文献

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ATN-224 (Choline tetrathiomolybdate, WTX-101)

生物&药学活性

物理化学性质&存储条件

参考文献

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