ATM inhibitor AZ31 | ATM inhibitor | ProbeChem Biochemicals

Chemical Structure : ATM inhibitor AZ31

CAS No.: 2088113-98-6

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ATM inhibitor AZ31 (AZ31, AZ-31)

货号: PC-70111Not For Human Use, Lab Use Only.

AZ31 is a potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

AZ31 is a potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM.
AZ31 displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR.
AZ31 reduces upregulation of p21 and blocks G1 arrest in wild-type but not Cdkn1a(p21CIP/WAF1)-/- mice.
AZ31 showes significant tumor growth reduction in the SW620 xenograft model combined with irinotecan.

物理化学性质&存储条件

分子量	420.513
分子式	C24H28N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide

参考文献

1. Degorce SL, et al. J Med Chem. 2016 Jul 14;59(13):6281-92.

2. Vendetti FP, et al. Sci Rep. 2017 Feb 1;7:41892.

3. Kiesel BF, et al. J Pharm Biomed Anal. 2017 May 10;138:158-165.

ATM inhibitor AZ31 (AZ31, AZ-31)

生物&药学活性

物理化学性质&存储条件

参考文献

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ATM inhibitor AZ31 (AZ31, AZ-31)

生物&药学活性

物理化学性质&存储条件

参考文献

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