欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAPKAPK2 (MK2)-ATI-450
ATI-450

Chemical Structure : ATI-450

CAS No.: 1640282-42-3

加入收藏

ATI-450 (CDD-450, Zunsemetinib, CDD450)

货号: PC-35136Not For Human Use, Lab Use Only.

Zunsemetinib (ATI-450, CDD-450) is an unique inhibitor that selectively blocks p38α activation of proinflammatory kinase MAPK-MK2 (MAPKAPK2, MK2) while sparing p38α activation of PRAK and ATF2.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zunsemetinib (ATI-450, CDD-450) is an unique inhibitor that selectively blocks p38α activation of proinflammatory kinase MAPK-MK2 (MAPKAPK2, MK2) while sparing p38α activation of PRAK and ATF2.
Zunsemetinib (ATI-450) is an orally bioavailable small molecule inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2, MK2) pathway.
Zunsemetinib (ATI-450, CDD-450) shows no effect on NLRP3 expression, but decreases IL-1β expression by promoting IL-1β mRNA degradation.
Zunsemetinib (ATI-450, CDD-450) accelerates TNF-α and IL-6 mRNA decay, inhibites inflammation in mice with cryopyrinopathy, and is as efficacious as global p38α inhibitors in attenuating arthritis in rats and cytokine expression by cells from patients with cryopyrinopathy and rheumatoid arthritis.

物理化学性质&存储条件

分子量 513.93
分子式 C25H22ClF2N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2'S)-3-Chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl[1(2H),4'-bipyridin]-2-one

参考文献

1. Wang C, et al. J Exp Med. 2018 May 7;215(5):1315-1325.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: