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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAPKAPK2 (MK2)-ATI-450
ATI-450

Chemical Structure : ATI-450

CAS No.: 1640282-42-3

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ATI-450 (CDD-450, Zunsemetinib, CDD450)

货号: PC-35136Not For Human Use, Lab Use Only.

Zunsemetinib (ATI-450, CDD-450) is an unique inhibitor that selectively blocks p38α activation of proinflammatory kinase MAPK-MK2 while sparing p38α activation of PRAK and ATF2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Zunsemetinib (ATI-450, CDD-450) is an unique inhibitor that selectively blocks p38α activation of proinflammatory kinase MAPK-MK2 while sparing p38α activation of PRAK and ATF2.
    Zunsemetinib (ATI-450) is an orally bioavailable small molecule inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2, MK2) pathway.
    Zunsemetinib (ATI-450, CDD-450) shows no effect on NLRP3 expression, but decreases IL-1β expression by promoting IL-1β mRNA degradation.
    Zunsemetinib (ATI-450, CDD-450) accelerates TNF-α and IL-6 mRNA decay, inhibites inflammation in mice with cryopyrinopathy, and is as efficacious as global p38α inhibitors in attenuating arthritis in rats and cytokine expression by cells from patients with cryopyrinopathy and rheumatoid arthritis.

    物理化学性质&存储条件

    分子量 513.93
    分子式 C25H22ClF2N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2'S)-3-Chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl[1(2H),4'-bipyridin]-2-one

    参考文献

    1. Wang C, et al. J Exp Med. 2018 May 7;215(5):1315-1325.

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