ATH-1105 | HGF signaling agonist | Probechem Biochemicals

Chemical Structure : ATH-1105

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ATH-1105 (Brelgometon, ATH1105)

货号: PC-27412Not For Human Use, Lab Use Only.

Brelgometon (ATH-1105) is a small-molecule, CNS-penetrant positive modulator of hepatocyte growth factor (HGF) signaling system, augments phosphorylation of MET, ERK, and AKT in vitro.

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生物&药学活性

Brelgometon (ATH-1105) is a small-molecule, CNS-penetrant positive modulator of hepatocyte growth factor (HGF) signaling system, augments phosphorylation of MET, ERK, and AKT in vitro.
ATH-1105 attenuated glutamate-mediated excitotoxicity in primary motor neurons and motor neuron- astrocyte cocultures, and had protective effects on motor neurons and neuromuscular junctions in motor neuron-muscle cocultures.
ATH-1105 mitigated LPS-induced inflammation in microglia- and macrophage-like cell systems.
ATH-1105 treatment resulted in improved motor and nerve function, sciatic nerve axon and myelin integrity, and survival in Amyotrophic lateral sclerosis (ALS) mice.
ATH-1105 reduced the levels of plasma biomarkers of inflammation and neurodegeneration, along with decreased pathological protein accumulation (phospho-TDP-43) in the sciatic nerve.

物理化学性质&存储条件

分子量	411.47
分子式	C21H28F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Pyrazino[1,2-a]pyrimidine-4,7(3H,6H)-dione, tetrahydro-6-methyl-8-[(2S)-2-methylbutyl]-1-[[4-(trifluoromethyl)phenyl]methyl]-, (6S)-

参考文献

1. Berthiaume AA, et al. Front Neurosci. 2024 Feb 8;18:1348157.

2. Berthiaume AA, et al. Front Neurol. 2026 Jan 8;16:1582765.

ATH-1105 (Brelgometon, ATH1105)

生物&药学活性

物理化学性质&存储条件

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ATH-1105 (Brelgometon, ATH1105)

生物&药学活性

物理化学性质&存储条件

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