AT7867 dihydrochloride |CAS:1431697-86-7 Probechem Biochemicals

Chemical Structure : AT7867 dihydrochloride

CAS No.: 1431697-86-7

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AT7867 dihydrochloride (AT-7867 dihydrochloride;AT 7867 dihydrochloride)

货号: PC-42874Not For Human Use, Lab Use Only.

AT7867 dihydrochloride is a potent, ATP-competitive, orally available dual Akt and p70S6K inhibitor with Ki of 17-85 nM, also inhibits PKA with Ki of 20 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AT7867 dihydrochloride is a potent, ATP-competitive, orally available dual Akt and p70S6K inhibitor with Ki of 17-85 nM, also inhibits PKA with Ki of 20 nM.
AT7867 potently inhibits both AKT and p70S6K activity at the cellular level, as measured by inhibition of GSK3beta (IC50=7.1 uM, pSer9 GSK3β in U87MG glioblastoma cells) and S6 ribosomal protein phosphorylation, causes growth inhibition in a range of human cancer cell lines.
AT7867 inhibits AKT and p70S6K and induces apoptosis, inhibits human tumor growth in PTEN-deficient xenograft models.

物理化学性质&存储条件

分子量	410.7678
分子式	C20H22Cl3N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-, hydrochloride (1:2)

参考文献

1. Grimshaw KM, et al. Mol Cancer Ther. 2010 May;9(5):1100-10.

2. Zhang Q, et al. Oncotarget. 2016 Jul 19;7(29):46127-46141.

3. Zhang S, et al. PLoS One. 2017 Jan 12;12(1):e0169585.

4. Kimura A, et al. Stem Cell Res. 2017 Oct;24:61-68.

AT7867 dihydrochloride (AT-7867 dihydrochloride;AT 7867 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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AT7867 dihydrochloride (AT-7867 dihydrochloride;AT 7867 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

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