AT13148 | AGC kinase inhibitor | Probechem Biochemicals

Chemical Structure : AT13148

CAS No.: 1056901-62-2

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AT13148 (AT-13148, AT 13148)

货号: PC-20556Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥2980	In stock
100 mg	￥6880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

AT13148 (AT 13148) is a potent, ATP-competitive and orally active multi-AGC kinase inhibitor with IC50 vaules of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
AT13148 potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines.
AT13148 dramatically suppresses activation of multiple AGC kinases, including Akt (at p-Thr-308), p70S6 kinase (p70S6K), glycogen synthase kinase 3β (GSK-3β) and p90 ribosomal S6 kinase (RSK) in gastric cancer cells.
AT13148 (40 and 50 mg/kg p.o.) inhibits phosphorylation of the AKT substrates GSK3β, tuberin, and the p70S6K target S6RP are also observed in PTEN-deficient MES-SA human uterine tumor xenografts.
AT13148 significantly inhibits HGC27 xenograft tumor growth in nude mice.

物理化学性质&存储条件

分子量	313.79
分子式	C17H16ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O[C@@](C1=CC=C(Cl)C=C1)(CN)C2=CC=C(C3=CNN=C3)C=C2

参考文献

1. Yap TA, et al. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.

2. Xi Y, et al. Biochem Biophys Res Commun. 2016 Sep 9;478(1):330-6.

AT13148 (AT-13148, AT 13148)

生物&药学活性

物理化学性质&存储条件

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AT13148 (AT-13148, AT 13148)

生物&药学活性

物理化学性质&存储条件

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